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May 20, 2014
November 24, 2010
Skip the black-five-sugars coffee and pop some NADH, a coenzyme that may increase mental alertness and concentration. In one New York-Presbyterian Hospital study, researchers tested 25 sleep-deprived people after the group had taken 20 milligrams of NADH and then again after they’d taken a placebo.
“When the people took NADH, they performed significantly better overall on a set of mental tests using a measure of speed and accuracy,” says Margaret Moline, Ph.D., one of the study researchers.
Look for supplements that say “ENADA” on the label; they contain the same NADH formulation used in studies.
November 24, 2010
The following is the Jet Lag Study Abstract presented at the 48th International Congress of Aviation and Space Medicine on September 19, 2000.
Effects of ENADAlertâ Sublingual on JET LAG
Research Team: Gary Kay, Ph.D., Clinical Neuropsychologist, Georgetown University Medical Center, Washington, DC
Eric Virre, M.D., Ph.D., Center for Neurologic Study, La Jolla, CA
Jonathan B. Clark, M.D., M.P.H., Neurologist/Flight Surgeon, NASA, Houston, TX
Objective: A double-blind placebo controlled study observing thirty-five subjects who took an overnight flight from San Diego, CA to Washington, DC (Red eye). This study is designed to measure alertness, problem solving, response time, and executive functions in healthy adults who have crossed time zones and were sleep deprived.
Methods: Cognitive exams that were administered to the subjects are validated tests used by the FAA for pilot re-certification and by the United States Air Force. Exams are designed to measure subtle changes in alertness, memory and response time. Base line test conducted in San Diego in early afternoon were repeated in Washington the following morning and afternoon after travelling cross-country.
Results: The ENADAlertâ group showed a statistically significant improvement over the placebo group in 10 out of 14 tests. The study will be submitted for peer review publication in the Aviation Space and Environmental Medicine Journal. Anticipated acceptance in September 2000. Coverage was printed by Wall Street Journal on the front page on 29th November 2000.
November 24, 2010
Interview: Dr. George Birkmayer on NADH for Energy, Healthy Immune Function and More
The following Q & A is with George Birkmayer, M.D., Ph.D. Dr. Birkmayer is the widely respected researcher and physician who first discovered the application of NADH in cellular development and energy transmission. He holds NADH use patents for a number of health conditions, and also produces the patented Enada brand of stabilized NADH.
“All we need is energy. Every living cell needs energy to stay alive. But exactly how is this energy for life produced? Hydrogen and oxygen react to form water and energy. The biological form of hydrogen is NADH, the abbreviation of nicotinamide-adenine-dinucleotide hydride. The oxygen comes from the air we breathe and is present in every living cell.” –George Birkmayer, M.D., Ph.D.
Q: I understand from an article you wrote that NADH was first discovered in 1905, and was found to be one of the most important coenzymes (“coenzyme 1”). Your extensive research and work has brought about the application of NADH to assist the production of energy and other vital functions in the human body. My first question is, how does NADH support the healthy function of the immune system?
A: Dr. Birkmayer: The immune system is based on the activities of our white blood cells, the main subgroup of which are lymphocytes and macrophages. Macrophages are responsible for the direct elimination of foreign bodies such as bacteria or viruses. They take them in and degrade them, a process comparable to eating and digesting. Therefore they have been named macrophages, which means big eating cells.
A direct relationship exists between the intake process of the macrophages and the activation of the immune system. When foreign agents such as bacteria or viruses enter the body the metabolic activity, including oxygen consumption of these eating cells, is markedly increased. Oxygen is converted to superoxide which destroys these bacteria and viruses. During this oxygen activation high amounts of NADH are consumed. Hence the more NADH the human organism has available, the better the immune system works.
During the processing of bacteria and viruses macrophages produce signal molecules which activate other cells of the immune system — the lymphocytes. These signal molecules are called cytokines. Cytokines are molecules in the human body necessary for the communication between different white blood cells.
The most important cytokines are the Interleukines, named after their functions to communicate between the various subgroups of the leucocytes. NADH stimulates the production of Interleukine IL-6 (dosage dependent up to 18.000 fold). Hence NADH possesses cytokine modulating effects on peripheral white blood cells, which are the key components of our cellular immune system. (Reference: Influence of reduced Nicotinamide Adenine Dinucleotide (NADH) on the production of Interleukin-6 by peripheral human blood leucocytes, Nadlinger K, Birkmayer J, Gebauer F , Kunze R Neuroimmunomodulation , ( 2002) 9: 203 – 208.)
Q: How does a deficiency in NADH cause problems with energy levels ?
Dr. Birkmayer: NADH is the fuel for cellular energy production. All living cells require energy to stay alive. Without energy a cell dies because energy production represents the essential prerequisite for every living cell.
How energy is produced involves food being taken in and digested. Its components, proteins, carbohydrates, and fats, are degraded into smaller molecules such as amino acids, sugars and lipids. They are processed leading to a reducing power in the form of NADH, the reduced form of coenzyme 1.
NADH reacts with oxygen, present in every living cell, to produce in a cascade of reactions water (H2O) and energy. This energy is stored in the form of the chemical compound adenosine triphosphate, abbreviated ATP. Scientific studies have shown that a loss of NADH leads to an ATP depletion, which in turn leads to cell death. (Metabolic and Energetic Changes During Apoptosis in Neural Cells, J.C. Mills, D. Nelson, M. Erecinska and R. Pittmanm, Journal of Neurochemistry, 1995). Simply put, the more NADH a cell has available, the more energy it can produce.
The question is: Can the energy level of a cell be increased by incubating the cell with NADH? If the answer is YES, it would mean that cells could produce more energy and due to this can live longer Most recent scientific studies have discovered that the energy level in a cell can actually be increased by NADH.
When isolated heart cells are incubated with NADH (NADH is outside the cell), the ATP concentration in these heart cells increases. In other words these heart cells have more ATP — energy. Hence they can function better and can liver longer. This is a sensational new discovery and has enormous implications for protection of the heart and other organs. If cells live longer organs live longer and due to this the entire organism. In other words NADH has a – scientifically proven – anti-aging effect.
Q: How does NADH help enhance mental clarity? What is the process through which NADH affects cognitive function?
Dr. Birkmayer: One third of all the energy we produce in our body is used up by our brain. Due to this an energy deficiency is first realized in the brain with symptoms such as lack of concentration and alertness, or mental fog (Newsweek Dec 17, 2001). NADH provides the brain more ATP energy in the same way as it does with heart cells.
With more NADH the brain cells function better. This has been demonstrated in a study performed at Cornell University in New York. When you suffer from sleep deprivation your cognitive performance goes down and the consequences are negative.
Nearly a third of the U.S. adults manage less than seven hours sleep each night according to the National Sleep Foundation and some 69 percent complain of frequent sleep problems. The consequences of sleep deprivation are many fold. Reduces alertness, concentration and reaction time increases the risk of an accident by 630 % (Teran-Santoz et al.), is the cause of 1/3 of all traffic accidents and of 1/4 of all fatal ones (Stoohs et al.)
A further mechanism by which NADH affects cognitive function is by stimulating the production of adrenaline and dopamine. Both of these substances are essential for our cognitive performance and our memory.
Q: What are the circumstances under which NADH levels in the body can drop or become depleted?
Dr. Birkmayer: There are two main reasons why NADH levels in the body can drop:
1. Over consumption of NADH due to an extreme energy demand (e.g., marathon run, severe illness and the like)
2. Reduced production due to a decreased or totally blocked metabolic pathway caused by toxins (environmental, food additives, drugs such as AZT and other cytostatics or antibiotics and the like).
Q: What are the conditions the body needs for normal healthy production and maintenance of NADH in cells?
Dr. Birkmayer: Sufficient amounts of nutrients such as carbohydrates, proteins and lipids in form of a balanced diet. All the enzymes involved in NADH biosynthesis must function at best performance. If these enzymes are inhibited by toxic substances such as drugs, NADH production declines. Minute amounts of NADH are taken up when eating meat, poultry or fish as these are rich in NADH. Vegetables have a very low content of NADH. Hence the uptake of NADH by vegetarian is neglected.
Q: How is NADH different from chemical stimulants (like caffeine) and how is it better?
Dr. Birkmayer: NADH is by all means much much better than caffeine or other stimulants for various reasons. Caffeine and the other stimulants containing ephedrine release adrenaline (also called epinephrine) from the nerve cells. This triggers a quick boost in adrenaline. You are less tired and more alert. However only for a very short time. The next coffee will not give you the same boost as the first one because your adrenaline pool in the nerve cells has been emptied. If the pool of adrenaline in your central nervous system is totally depleted, you can drink as much coffee as you want but you will not get any more boost.
NADH on the other hand stimulates the biosynthesis of adrenaline and due to this fills the pool of adrenaline in the central nervous system. This is the essential prerequisite for caffeine to become active.
In addition, NADH increases the real ATP energy in the cells. With more energy the nerve cells do produce not only more adrenaline, dopamine and also serotonin but other components necessary for good performance. NADH is the only substance which has been shown to increase cellular energy. Coffee, and all the so called energy drinks, do not increase cellular energy. In fact they do nothing but release adrenaline from nerve cells and are therefore mere stimulants. Too much and to high stimulation can cause considerable side effects or adverse reactions such as irregular heart beat.
Q: NADH is described as an active vitamin — what does that mean ?
Dr. Birkmayer: NADH is the abbreviation of Nicotinamide-Adenine-Dinucleotide-Hydride. Nicotinamide is another name for vitamin B3. Hence, NADH is the coenzyme form or active form of vitamin B3. Vitamin B3 itself is inactive. As a vitamin it is essential for our body. It is absorbed and converted in the cells to NAD (oxidized form of NADH). NAD is then converted to NADH. However, it cannot be emphasized enough that neither Nicotinamide nor NAD (oxidized form of NADH) shows the energizing effect of NADH not even in very high dosages as we have tested in our numerous studies.
Q: How is NADH different from Coenzyme Q10 ?
Dr. Birkmayer: Both support cellular energy production. Coenzyme Q10 is involved in cellular energy production however at a much lower level than NADH. Coenzyme Q10 needs NADH to be transformed into its reduced form. Only in its reduced form CoQ10 is active and can transport electrons from NADH to oxygen which then leads to energy production in form of ATP.
[I believe] CoQ10 should always be taken with sufficient amount of ENADA NADH, the only stabilized, absorbable form of NADH. In contrast NADH can produce energy without CoQ10 even without oxygen (under anaerobic conditions). When highly conditioned athletes perform for too long (marathon runners, or cyclists) their muscles come under anaerobic conditions. Even under these circumstances NADH can produce ATP energy, whereas CoQ10 is unable to do so under anaerobic conditions. NADH is by far superior in producing cellular energy.
However, CoQ10 will add to the energy producing capacity of NADH when taken in conjunction. NADH however has many more functions in the body in addition of producing energy. It does repair cell and DNA damage, it stimulates the immune system, it stimulates the biosysnthesis of the neurotransmitter, adrenaline, dopamine and serotonin. It stimulates the production of NO (Nitric Oxide) which induces relaxation of blood vessels in many organs such as heart, lung, brain and kidney.
Q: Is there anything else our reader should know or understand about NADH?
Dr. Birkmayer: NADH has been shown to increase energy in form of ATP inside of heart cells and these cells have been shown to live longer. Based on these unique findings a patent for extending the lifespan of cells, tissues and organs (anti-aging) is pending. This will be the first and so far only nutritional supplement with a scientifically proven anti-aging effect.
November 15, 2010
Investigators Discover Potential Indicator for Chronic Fatigue Syndrome
CHICAGO, Ill. – The discovery of a potential indicator for chronic fatigue syndrome is among new findings presented at the American College of Allergy, Asthma and Immunology’s (ACAAI) Annual Meeting in Chicago.
Chronic fatigue syndrome (CFS) is a debilitating disorder that causes unexplainable tiredness or lack of energy. It affect s more than 14 million Americans, occurring mainly in adults aged 20 to 40 years and in twice as many women as men.
“Currently, the diagnosis of CFS involves a lengthy procedure of eliminating other possible causes of severe fatigue lasting more than six consecutive months,” said ACAAI Past President Joseph A. Bellanti, M.D., of Georgetown University Medical Center in Washington, D.C. “Hopefully this data will provide a predictive marker of CFS which will help unravel the diagnosis and treatment of this perplexing disorder.”
Investigators used data from a double blind placebo controlled study published February 1999, in the ACAAI’s scientific journal, “Annals of Allergy, Asthma and Immunology.” The study reported subjects taking a nutritional supplement ENADA® – a stabilized oral absorbable form of nicotinamide adenine dinucleotide (NADH) – were four times more likely to show an improvement in CFS symptoms than those taking a placebo.
According to Dr. Bellanti, the follow-up study testing urinary concentrations in 20 of the CFS patients found that 75 percent showed elevated levels of a major breakdown product of serotonin, known as 5-HIAA. When treated with NADH, 70 percent of the patients returned to normal range, whereas in the placebo subjects, 70 percent retained elevated or increasing levels.
“The results of this study suggest that the measurement of urinary 5-HIAA may not only serve as a useful predictive marker of disease activity in CFS patients, but also may provide an objective measure of improvement following therapy with NADH,” said Dr. Bellanti.
The Centers for Disease Control and Prevention (CDC) defined criteria for the diagnosis of chronic fatigue syndrome. Unexplained, debilitating fatigue of at least six month duration must be present, along with four or more of the following symptoms: neurocognitive dysfunction, muscle pain, sore throats, headaches, feeling of being sick or of physical discomfort after exertion, joint pain, sleep disturbances, or swelling and tenderness of lymph nodes.
For assistance in locating an allergist-immunologist, call the ACAAI toll-free number (800) 8427777 or visit its public web site at http://allergy.mcg.edu.
The ACAAI is a professional medical organization comprised of 4,100 qualified allergistsimmunologists and related health care professionals. The College is dedicated to the clinical practice of allergy, asthma and immunology through education and research to promote the highest quality of patient care.
Full-text articles published in “Annals of Allergy, Asthma & Immunology” are available free to media on the Internet at www.annallergy.org through December 2000. Thereafter, access will be limited to subscriptions.
November 13, 2010
A recent clinical study reports that ENADA, a dietary supplement, provides relief for Chronic Fatigue Syndrome (CFS). ENADA, is the only patented, stabilized absorbable, oral form of NADH available. NADH is a naturally occurring coenzyme involved with the body’s energy producing cycle. The more NADH a cell has the more energy it can produce. ENADA is one of the first nutritional supplements to be tested using strict FDA guidelines to determine its safety and effectiveness.
Below is an article, which appeared in the Washington NY times Syndicate on February 24, 1999, pertaining to the CFS study findings:
“Supplement May Energize Some Chronic-fatigue Patients” – A dietary supplement may benefit victims of chronic fatigue syndrome, researchers announced at a news conference here Tuesday. “We’ve demonstrated a real benefit with NADH in this study”, said Dr. Joseph A. Bellanti of the Georgetown University School of Medicine, who led the study of chronic fatigue patients. NADH is a compound found naturally in food that plays a central role in the process by which cells convert food into energy. A poorly understood ailment, CFS symptoms afflict some 500,000 people nationwide, according to Centers for Disease Control and Prevention in Atlanta. Doctors can only diagnose the disease by these symptoms, which includes headaches, body aches, poor concentration, sore throats and lethargy lasting at least six months. Bellanti and his colleagues described the results of a three-month trial of NADH. Of 26 patients given the supplement, eight reported significant lessening of their symptoms, compared with only two of 28 control patients who were taking a placebo. Furthermore, 72 percent of patients in a follow-up study reported that their symptoms improved.
Bellanti and his colleagues theorize that CFS is nothing more than al lack of the chemical adenosine triphosphate (ATP), which provides power to the body. Chronic infections, stress, and other ailments tend to deplete the chemical, according to the researchers. NADH, short for nicotinamide adenine dinucleotide, is the chemical that jumpstarted the production of ATP in muscles, so the researchers hypothesized that simply providing supplements of the chemical might people with chronic fatigue. Patients in the study received 10 milligrams of NADH a day. “They may have stumbled onto something useful”, said Ronald Glazer, a virologist and immunologist at Ohio State University School of Medicine. He argued that so little is currently available to treat the syndrome that CFS patients should consider taking the supplement now.
Healthy individuals desiring more natural energy also benefit from taking ENADA – Over two thirds of the people take ENADA for overall energy enhancement as well as mental clarity. ENADA has been sold in the U.S. since 1995 and tens of thousands of customers are taking ENADA for increased energy. Consumer research indicated that 76% of consumers taking ENADA report improvement in their energy levels. For more information on ENADA and the CFS Georgetown study visit their website at www.enada.com